Chronic Nasal Granulomatous Disease Rhinosporodiosis

Chronic Nasal Granulomatous Disease Rhinosporodiosis
Chronic Nasal Granulomatous Disease Rhinosporodiosis

What is Granuloma?

Granuloma is a specific type of chronic inflammation characterized by the local accumulation of macrophages, epithelial cells and multinucleated giant cells surrounding with a zone of lymphocytes.

What are the common granulomatous conditions?

A. Specific

  1. Rhinosporodiosis, Aspergillosis
  2. Tuberculosis
  3. Syphilis
  4. Leprosy
  5. Leishmaniasis
  6. Rhinoscleroma

B. Non specific

  1. Sarcoidosis
  2. Wegner’s granuloma

C. Lethal midline granuloma
D. Stewart’s granuloma

What is Rhinosporodiosis?

Rhinosporodiosis is a chronic granulomatous fungal infection of the nasal mucosa presenting as vascular soft polypoid mass caused by Rhinosporidium seeberi. It was first described by Seeber in Argentina in 1990. It is Endemic in Bangladesh, India, Sri Lanka, South America and Africa. Men are more suffered than female. The male female ratio is about 4:1.

ICD-10 Code: B48.1

Chronic Nasal Granulomatous Disease Rhinosporodiosis
Chronic Nasal Granulomatous Disease Rhinosporodiosis

What is the Pathophysiology?

Infection usually results from a local traumatic inoculation with the organism. The disease progresses with the local replication of the organism and associated hyperplastic growth of host tissue. The spore of the fungas present in the cowdung of animals like cows, buffalo, dogs etc. If the people take bath in the pond or river infected with the spore they can get this infection. It is more prevalent in Winter. Eye infection can get from dust or air and more common in summer.

What are the sites of Rhinosporodiosis in our body?

  1. Nose and nasopharynx
  2. Eye- conjunctiva, lacrimal apparatus
  3. Mouth, upper airway, skin, genitalia

What are the clinical features ?


  1. Unilateral nasal obstruction.
  2. Recurrent epistaxis.
  3. Sneezing, Rhinorrhea and post nasal discharge.
  4. Patient may describe as foreign body being felt in the nasal passages.
  5. Local pruritus and coryza.


Reddish vascular soft polypoid mass present in the nasal cavity. Its surface is granular, looks like strawberry. It bleeds on touch. They are sessile or pedunculated. Pedicle is attached to nasal septum, inferior turbinate, lateral wall of the nose or coming from the nasopharynx. Its under surface shows grey or yellow spots of sporangia.

How to Diagnose Rhinosporodiosis?

It can be easily diagnosed by microscopic observation of the organism. Diagnosis is clinically done by observation. Swab is taken and Histopathology done after excision.

What is the Treatment plan?

The treatment of choice is Complete Excision and Electrocoagulation of its base to reduce recurrence and bleeding.


1. Recent advances in rhinosporidiosis and rhinosporidium seeberi  at Indian Journal of Medical Microbiology


3. Rhinosporidiosis at Wikipedia

About Dr. Alamgir Hossain Shemul 94 Articles
Passionate about Child Health and Well Being. MD Resident of Pediatric Hematology and Oncology in BSMMU. Passed MBBS from Rajshahi Medical College. Completed FCPS Part 1 in Paediatrics. Ex-Honorary Medical Officer at Dhaka Medical College Hospital and NICU Medical officer at Anwer Khan Modern Hospital, Dhaka.

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