Drugs-Pediatric Medicine

Chemotherapy Drugs for Childhood Cancer Antitumor Antibiotics Anthracyclines

There are many classes of anti cancer chemotherapy drugs. Some of them are cell cycle specific some are not. They act in different ways. One of the subclass is antitumor antibiotics. Topoisomerases are nuclear enzymes that regulate the three dimensional shapes of DNA by cleaving and relegating DNA during replication, transcription, repair, and recombination. Topoisomerase […]

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Chemotherapy Drugs for Childhood Cancer Vincristine

Chemotherapy drugs are center point of treatment for childhood cancer. There are many classes of chemotherapy drugs available. Microtubules, which are an integral component of the cytoskeleton, play important roles in a variety of cellular functions including mitosis, cellular transport, maintenance of cell shape, polarity, and cell signaling. Traditional tubulin inhibitors include the vinca alkaloids,

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Chemotherapy Drugs for Childhood Cancer 6-MP, Cytarabine, Fluorouracil

Childhood cancer is curable. Modern development in the pharmacotherapy and newer treatment modalities have made it possible to remove the burden of cancer in most cases. This is a series of discussion about chemotherapeutic agents used in the treatment of childhood cancer. Cancer treatment is different from other Paediatric diseases. It needs special care specially

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Chemotherapy Drugs Cyclophosphamide Cisplatin Carboplatin

All alkylating agents have alkyl groups, and they can transfer this alkyl group to a suitable receptor site. Alkylating agents in neutral or alkaline solution form highly reactive carbonium ions, which are quaternary ammonium derivatives. This carbonium ion is highly reactive and can react with groups like NH₂, SH, OH, or PO₄ in physiologically important

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Imatinib and Methotrexate Concurrent Use in Leukemia

Imatinib is a tyrosine kinase inhibitor mainly used in Chronic Myeloid Leukemia (CML), gastrointestinal tumors, Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL), Hypereosinophilic Syndrome etc. But the problem is its a expensive drug. Its available is Gleevec in USA. But the price in Bangladesh is comparetively lower. Acute lymphoblastic leukemia (ALL) is the most common

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WHO List of Essential Medicines & Drugs For Children [Updated 2023]

Update: Essential Medicine List for Children has published the lastest 9th Edition, July 2023. World Health Organisation in short popularly known as WHO has been publishing the Essential Medicines List for both Children and Adults. It has been updated every 2 years. The first list of Essential Medicines list was published in 1977 only for

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